MK2866 & MK677 60 Capsules (Zeus)
MK677 (10mg) & MK677 (10mg) 60 Capsules
What is Ibutamoren?
Ibutamoren is frequently discussed on online forums for its muscle-building properties. It is available over the counter and used by those wishing to increase their growth hormone levels.
However, clinical studies of this compound are relatively few. In the text below, we will highlight what is known about ibutamoren so far.
Ibutamoren (also known as ibutamoren mesylate or MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1).
Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition . Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.
A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol . Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.
Potential Uses of Ibutamoren
1) Building Muscle
Ibutamoren is frequently used as an anabolic substance, to increase lean body mass i.e. create bigger muscles. It is orally active and can be taken once a day. These are all benefits compared to other growth hormone stimulators.
As previously mentioned, ibutamoren increases growth hormone levels and IGF-1 . Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat.
In 24 obese men, a two-month treatment (double-blind randomized controlled trial) with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR).
2) Muscle Wasting
In a study (double-blind randomized controlled trial) in eight food-deprived healthy volunteers, ibutamoren reversed diet-induced protein loss, that could cause muscle wasting.
In 123 elderly patients with hip fracture (randomized controlled trial), ibutamoren improved gait speed, muscle strength and reduced the number of falls.
3) Bone Density
Growth hormone (GH) increases bone turnover and eventually bone density. However, because of the increased turnover in subjects treated with growth hormone, bone density can initially decrease before increasing. Basically, it takes time (> 1 year) to see the bone density increase.
In 24 healthy obese male volunteers, ibutamoren increased bone turnover (double-blind randomized controlled trial).
In 187 elderly adults (65 years or older), ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover in multiple studies (3 double-blind randomized controlled trials).
In one study (double-blind randomized controlled trial) with 292 post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosin.
A study (double-blind randomized controlled trial) showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration.
Apart from scientific studies, there have been many reports of subjective improvements in sleep quality, across various online forums.
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Growth Hormone (GH) secretion and muscle mass both decline from mid-puberty throughout life.
In a study with 65 elderly men and women (double-blind randomized controlled trial), daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects. IGF-1 is known to have beneficial effects on longevity.
In another study with 24 obese males (double-blind randomized controlled trial), ibutamoren rejuvenated the growth hormone profile.
6) Nootropic Effects
Some people use ibutamoren as a nootropic because it acts on the ghrelin receptor, which has nootropic effects. You can read more about these effects in the post on ghrelin. Science is, however, yet to study if and how ibutamoren affects cognitive performance.
Two indirect mechanisms by which ibutamoren can improve brain function:
- Ibutamoren increases IGF-1, which is known to improve memory and learning.
- Ibutamoren also increases REM sleep duration and sleep quality. And we know that sleep is essential for good cognitive function.
A study (multicenter double-blind randomized controlled trial) questioned the association of low IGF-1 and Alzheimer’s disease, and whether ibutamoren could be of help. However, in this study, ibutamoren was ineffective at slowing the progression of Alzheimer’s in humans .
7) Growth Hormone Deficiency
Ibutamoren can increase growth hormone, IGF-1, and IGFBP-3 levels in children with growth hormone deficiency. Furthermore, these effects are achieved without changing the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin.
In severely GH-deficient men, ibutamoren increased IGF-1 and growth hormone, with no significant changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose were increased (double-blind randomized controlled trial).
8) Wound Healing and Tissue Regeneration
Growth hormone increases tissue regeneration and wound healing , so ibutamoren may help with these.
There are individual reports of ibutamoren being helpful, but scientific studies are lacking.
This one is anecdotal, but people report curing hangovers with ibutamoren.
What Is Ostarine?
Ostarine (MK-2866), also known as enobosarm, is a selective androgen receptor modulator (SARM). SARMs like Ostarine stimulate steroid hormone receptors – androgen receptors — mimicking testosterone.
Unlike typical steroids, though, SARMs can target specific tissues, such as the muscles or bones. This limits their side effects, which means that people who take SARMs don’t have to deal with severe testosterone suppression and increased estrogens. Due to their favorable safety and “cleaner” gains, SARMs have surfaced as a popular new class of appearance and performance enhancers.
Many bodybuilders and athletes swear by Ostarine and claim it offers significant muscle mass and performance gains with few risks. Based on its mechanism of action, Ostarine should be safer than steroids. Although it’s also potentially safer than other SARMs, it has not yet been approved for human use anywhere in the world.
Ostarine and other SARMs are being researched for their ability to improve serious muscle wasting diseases. Ostarine was initially developed to target muscle wasting diseases and prevent complete muscle loss. Interestingly enough, it is one of the few SARMs still in clinical trials (by GTx) while most others proved to be too toxic.
Ostarine may be approved for clinical use in the future if the ongoing clinical trials attest to its favorable benefits/risks ratio. However, its use in professional sports will almost certainly remain illegal. As things currently stand, the World Anti-Doping Agency banned Ostarine under the S1 Anabolic Agent category of the Prohibited List, along with all other SARMs back in 2008.
- Increases lean muscle mass and strength
- Shouldn’t cause hormonal imbalance
- May improve bone strength
- May lower cholesterol and improve insulin resistance
- Only mild side effects have been reported
- Not allowed for use in professional sports
- Not approved for human use or consumption in any country
- Long-term risks are unknown
Ostarine Mechanism of Action
It’s no secret that androgens increase skeletal muscle mass – that’s the main physiological reason why men typically have more muscles than women. Being the main male sex hormones, the activity of androgens in the body go well beyond muscle-building. When sensors for androgens are non-selectively stimulated by drugs like steroids, the result is usually a long list of side effects.
SARMs specifically target muscles and increase anabolic processes while sparing the reproductive organs. Among many synthesized SARMs, the structure of Ostarine seems to offer some advantages. Scientists are still trying to understand why in the hopes of uncovering newer and even more effective muscle-selective drugs.
Animal studies shed some light on exactly what Ostarine does in the muscles. In one study on mice, Ostarine was as effective as the most influential androgen, dihydrotestosterone, at restoring the size of pelvic floor muscles. Muscles in the pelvic floor are especially rich in androgen receptors (AR).
Ostarine could also activate muscle stem cells (satellite cells), which help remodel and regenerate muscles. Surprisingly, it turned out that Ostarine also stimulates cells in the connective tissue, which are important for successful recovery from muscle injuries.
Ostarine increased the activity of the insulin-like growth factor 1 gene (IGF-1), which boosts muscle growth and strength.
Potential Uses of Ostarine
This section focuses on the clinical and scientific research that backs up the potential use of Ostarine for muscle-wasting diseases.
1) Muscle Mass
Ostarine is being researched for reversing muscle loss in cancer patients, people with muscular dystrophy, and the aging population.
In a clinical trial of 120 healthy elderly people (double-blind randomized controlled trial), enobosarm increased lean muscle mass and fitness. Only those who received 3 mg of enobosarm daily for 12 weeks saw benefits, while lower doses did not work as well. Importantly, its side effects were similar to placebo, with no steroid-like risks.
In another trial, enobosarm safely increased lean muscle mass in 159 cancer patients. Cancer patients who already started to lose muscle mass prior to the study gained about 2 – 3 lbs after taking enobosarm for about 4 months. The lower (1 mg/day) and the higher (3 mg/day) dose worked equally well.
Large clinical trials of enobosarm for preventing muscle loss in cancer patients are currently underway.
In rats, oral enobosarm was quickly and completely absorbed. It could be widely distributed throughout the body and eliminated via detox pathways.
2) Bone Health
A decrease in bone-protective sex hormones with age increases the risk of poor bone health and osteoporosis. While enhancing bone mineralization is important, increasing muscle mass can reduce the risk of bone fractures and speed recovery. Muscles support the whole skeletal system and their strength and good health aid in healing fractures, especially in older people.
Since Ostarine mimics testosterone in the muscles and bones, it has the potential to prevent bone diseases. Animal studies confirmed that SARMs like Ostarine could increase both muscle and bone strength. No human study has confirmed the benefits yet, though.
3) Heart Health
Ostarine may also prove to be beneficial for people with heart disease, who often suffer from muscle wasting and weight loss.
In a clinical trial of 120 healthy elderly people (double-blind randomized controlled trial), enobosarm (1-3 mg/day) lowered lipids in the blood such as triglycerides, total cholesterol, and HDL cholesterol. Healthy lipid levels help prevent heart disease. However, lowering HDL is not typically considered beneficial.
4) Insulin Resistance
In the same above-mentioned study of 120 healthy elderly people (double-blind randomized controlled trial), enobosarm improved insulin resistance and lowered blood glucose. The effects were similar to standard anti-diabetic drugs such as metformin. Ostarine may benefit people with diabetes or metabolic syndrome with more research.
Advanced Ostarine Research
- Ostarine has good bioavailability. Rats completely absorbed Ostarine, transported it throughout the body, and eliminated it via feces mostly as an unchanged drug.
- Dosage in clinical studies: Ostarine 1 mg/day increased total lean body mass by more than 3 pounds, while 3 mg/day increased it by only 2 pounds after almost 3 months in cancer patients. Elderly people gained muscle mass only on 3 mg/day.
- Ostarine and other SARMs are also being researched for potentially helping those with breast cancer, incontinence, low testosterone in older men, and muscular dystrophy (such as Duchenne Muscular Dystrophy).
Use for 12 weeks maximum. Take 2 caps daily with meals. PLEASE NOTE a full PCT is needed (Beast Yourself Testo Beast 450g).
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